作者：pmo4b69bd 来源：药学院 校对：无 审核：暂无 发布时间：2021-10-10
一、个人简介
郭宏伟，中药学博士，教授，博士生导师，博士后合作导师，现任登入入口副院长。入选国家青年岐黄学者、广西青年岐黄学者、广西千名中青年骨干教师培育计划人选和南宁市新世纪学术和技术带头人。曾留学于美国密歇根大学和澳大利亚墨尔本大学，现兼任“广西中药组效学重点研究室”主任、“广西生物活性分子研究与评价”重点实验室常务副主任、“长寿与老年相关疾病”教育部重点实验室课题组负责人（PI）。一直从事中药学和生药学相关的教学和科研工作，研究方向为中药民族药防治肿瘤基础与转化研究。近年来先后主持国家自然科学基金，广西重点研发项目、广西自然科学基金重点项目等课题25项。发表科研论文100余篇，其中SCI收录50余篇。出版教材和学术专著8部。授权国家发明专利10项，实施专利成果转化1项。牵头制定行业标准2项。获中国民族医药学会科学技术二等奖1项，广西医药卫生适宜技术推广奖三等奖1项。目前担任《中国癌症防治杂志》编委，《Chinese Medicine》、《Chinese Herbal Medicines》和《Chinese Medicine and Culture》青年编委等。先后培养博士后5名，博士生4名，硕士生26名。
二、近5年代表性科研项目（主持）
(1) 国家青年岐黄学者培养项目（国家中医药管理局2022年）。
(2) 国家自然科学基金（82160948），傣药傣百解（通关藤）靶向GSK-3β/STAT3信号轴诱导前列腺癌凋亡和抑制转移的分子机制。
(3) 国家自然科学基金（82074347），基于网络药理学探讨荔枝核多靶协同调控乳腺癌干性和EMT的分子机制。
(4) 广西重点研发计划项目（桂科AB20238004），濒危药用植物七叶一枝花种苗繁育关键技术研究及高效栽培基地示范。
(5) 广西自然科学基金重点项目（2023GXNSFDA026047），通关藤提取物抑制细胞自噬促进FOXO3a核转位诱导前列腺癌凋亡的分子机制。
三、近5年代表性论文（通讯作者）
(1) Xue W, Zhu B, Zhao K, Huang Q, Luo H, Shou Y, Huang Z, Guo H. Targeting LRP6: A new strategy for cancer therapy. Pharmacol Res. 2024 May 6;204:107200. doi: 10.1016/j.phrs.2024.107200.
(2) Zhang W, Chen T, Yang P, Li X, Zhu D, Su Z, Yang X, Jin R, Lan T, Guo H. Total flavonoids of Litchi chinensis Sonn. seed inhibit prostate cancer growth in bone by regulating the bone microenvironment via inactivation of the HGFR/NF-κB signaling pathway. J Ethnopharmacol. 2024 Jan 30;319(Pt 3):117327.
(3) Hou Y, Wang H, Wu J, Guo H, Chen X. Dissecting the pleiotropic roles of reactive oxygen species (ROS) in lung cancer: From carcinogenesis toward therapy. Med Res Rev. 2024 Jan 29. doi: 10.1002/med.22018.
(4) Guo S, Zhang Q, Li X, Yu X, Lan T, Zhang W, Han Y, Chen X, Yang X, Guo H. A network pharmacology-based approach to explore the molecular mechanism of Aidi injection against prostate cancer. Heliyon. 2024 Apr 15;10(8):e29720.
(5) Zhang Q, Huang Q, Cheng Z, Xue W, Liu S, Liao Y, Li X, Chen X, Han Y, Zhu D, Su Z, Yang X, Luo Z, Guo H. Exploring the mechanism of Xiaoaiping injection inhibiting autophagy in prostate cancer based on proteomics. Chin J Nat Med, 2023, 22(0): 1-17.
(6) Cui D, Luo Z, Liu X, Chen X, Zhang Q, Yang X, Lu Q, Su Z, Guo H. Combination of metabolomics and network pharmacology analysis to decipher the mechanisms of total flavonoids of Litchi seed against prostate cancer. J Pharm Pharmacol. 2023 May 11:rgad035.
(7) Liao Y, Luo Z, Liu Y, Xue W, He S, Chen X, Ren H, Yang X, Zhu D, Su Z, Huang Q, Guo H. Total flavonoids of Litchi seed attenuate stem cell-like properties in breast cancer by regulating Notch3 signaling pathway. J Ethnopharmacol. 2023 Apr 6;305:116133.
(8) Li X, He S, Liang W, Zhang W, Chen X, Li Q, Yang X, Liu Y, Zhu D, Li L, Liu B, Su Z, Chen J, Guo H. Marsdenia tenacissima injection induces the apoptosis of prostate cancer by regulating the AKT/GSK3β/STAT3 signaling axis. Chin J Nat Med. 2023 Feb;21(2):113-126.
(9) Xue W, Hao J, Zhang Q, Jin R, Luo Z, Yang X, Liu Y, Lu Q, Ouyang Y, Guo H. Chlorogenic Acid Inhibits Epithelial-Mesenchymal Transition and Invasion of Breast Cancer by Down-Regulating LRP6. J Pharmacol Exp Ther. 2023 Feb;384(2):254-264.
(10) Lu Q, Wu G, Hao X, Hu X, Cai H, Liu X, You X, Guo H, Sun C. Isolation, Structure Elucidation, and First Total Synthesis of Quinomycins K and L, Two New Octadepsipeptides from the Maowei Sea Mangrove-Derived Streptomyces sp. B475. Mar Drugs. 2023 Feb 23;21(3):143.
(11) Chen X, Luo Z, Liu X, Li X, Li Q, Zhang W, Liu Y, Cheng Z, Yang X, Liu Y, Jin R, Zhu D, Wang F, Lu Q, Su Z, Guo H. Marsdenia tenacissima (Roxb.) Moon injection exerts a potential anti-tumor effect in prostate cancer through inhibiting ErbB2-GSK3β-HIF1α signaling axis. J Ethnopharmacol. 2022 Sep 15;295:115381.
(12) Li Q, Lan T, He S, Chen W, Li X, Zhang W, Liu Y, Zhang Q, Chen X, Han Y, Su Z, Zhu D, Guo H. A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model. Chin Med. 2021 Oct 9;16(1):99.
(13) Zhang C, Mo Y, Feng S, Meng M, Chen S, Huang H, Ling X, Song H, Liang Y, Ou S, Guo H, Su Z. Urinary metabonomics study of anti-depressive mechanisms of Millettia speciosa Champ on rats with chronic unpredictable mild stress-induced depression. J Pharm Biomed Anal. 2021 Oct 25;205:114338.
(14) Chang M, Zhu D, Chen Y, Zhang W, Liu X, Li XL, Cheng Z, Su Z, Zhang J, Lu Y, Guo H. Total Flavonoids of Litchi Seed Attenuate Prostate Cancer Progression Via Inhibiting AKT/mTOR and NF-kB Signaling Pathways. Front Pharmacol. 2021 Sep 23;12:758219.
(15) Zhang S, Gan Y, Shao L, Liu T, Wei D, Yu Y, Guo H, Zhu H. Virus Mimetic Shell-Sheddable Chitosan Micelles for siVEGF Delivery and FRET-Traceable Acid-Triggered Release. ACS Appl Mater Interfaces. 2020 Dec 2;12(48):53598-53614.
(16) Lan T, Li Q, Chang M, Yin C, Zhu D, Wu Z, Li X, Zhang W, Yue B, Shi J, Yuan H, Su Z, Guo H. Lei-gong-gen formula granule attenuates hyperlipidemia in rats via cGMP-PKG signaling pathway. J Ethnopharmacol. 2020 Oct 5;260:112989.
(17) Cao S, Han Y, Li Q, Chen Y, Zhu D, Su Z, Guo H. Mapping Pharmacological Network of Multi-Targeting Litchi Ingredients in Cancer Therapeutics. Front Pharmacol. 2020 Apr 24;11:451.
(18) Huang H, Wu J, Lu R, Liu X, Chin B, Zhu H, Yin C, Cheng B, Wu Z, Chen X, Liang Y, Song H, Zheng H, Guo H, Su Z. Dynamic urinary metabolomics analysis based on UHPLC-Q-TOF/MS to investigate the potential biomarkers of blood stasis syndrome and the effects of Danggui Sini decoction. J Pharm Biomed Anal. 2020 Feb 5;179:112986.
(19) Zhu H, Han W, Gan Y, Li Q, Li X, Shao L, Zhu D, Guo H. Combined Modality Therapy Based on Hybrid Gold Nanostars Coated with Temperature Sensitive Liposomes to Overcome Paclitaxel-Resistance in Hepatic Carcinoma. Pharmaceutics. 2019 Dec 15;11(12):683.
(20) Yun C, Chang M, Hou G, Lan T, Yuan H, Su Z, Zhu D, Liang W, Li Q, Zhu H, Zhang J, Lu Y, Deng J, Guo H. Mangiferin suppresses allergic asthma symptoms by decreased Th9 and Th17 responses and increased Treg response. Mol Immunol. 2019 Oct;114:233-242.
联系方式
1. 邮箱：hongweiguo@gxmu.edu.cn
2. 办公电话：0771-5605911
3. 通讯地址：广西南宁市双拥路22号
